Tuesday, 28 April 2020

Locked Onto Influenza?


by Les May

SPARROW Hawks and birds which hunt like them seem to have the ability to lock onto a specific target and however much it weaves and dives remain doggedly on its tail.  Did something similar happen in January and February when the response to the potential for a Covid-19 pandemic was being thrashed out in the UK?  Was there a fixation on the type of response which has worked in the past with respect to Influenza epidemics.  Essentially that amounts to ‘you can’t stop Influenza, so rely on mitigating the harm it causes’Did the UK government’s advisers ‘lock on’ to an Influenza response strategy and fail to consider possible alternatives?

There are two important differences between Covid-19 and Influenza.  Covid-19 has a higher death rate and a longer incubation period than Influenza.  The first means it is even more dangerous, the second that there is a longer window in which to test, trace and track potential sufferers.

I am prompted to ask these questions because New Zealand, which followed a different strategy after abandoning mitigation, now believes that it has largely eliminated community transmission of the virus and is in the process of easing its ‘lockdown’ measures.  Of course New Zealand has a much smaller population than the UK, but if we standardise the infection rate in terms of cases per million of the population we find that for New Zealand the numbers are about 300 per million and for the UK they are about 2,300 per million.

The strategy followed by New Zealand was ‘containment as a stepping stone to elimination’.

The steps needed to make such a strategy work were discussed in a paper published in the New Zealand Medical Journal on 3 April 2020.  Some of the requirements for making elimination work which were presented in that paper are:

Elimination is a well-recognised strategy for infectious disease control, and New Zealand can draw on public health experience of eliminating a range of human and animal infectious diseases.  In particular there are lessons to be learned from the measles and rubella elimination strategy, albeit with the difference that we do not yet have an effective vaccine for COVID-19.  Past experience has taught us that there are three factors that are critical to elimination success: 1) high-performing epidemiological and laboratory surveillance systems; 2) an effective and equitable public health system that can ensure uniformly high delivery of interventions to all populations, including marginalised groups (in this instance intervention is focused on diagnosis, isolation of cases and quarantine of contacts rather than vaccine); and 3) the ability to sustain the national programme and update strategies to address emerging issues.

The essential elements of an elimination strategy for COVID-19 are likely to include:
1. Border controls with high-quality quarantine of incoming travellers;
2. Rapid case detection identified by widespread testing, followed by rapid case isolation, with swift contact tracing and quarantine for contacts;
3. Intensive hygiene promotion (cough etiquette and hand washing) and provision of hand hygiene facilities in public settings;
4. Intensive physical distancing, currently implemented as a lockdown (level 4 alert) that includes school and workplace closure, movement and travel restrictions, and stringent measures to reduce contact in public spaces, with potential to relax these measures if elimination is working;
5. A well-coordinated communication strategy to inform the public about control measures and about what to do if they become unwell, and to reinforce important health promotion messages. (my emphasis)


I have repeatedly suggested that we should watch carefully what is happening in China and not get too ‘hung up’ on the accuracy of the figures it publishes.  This is what the authors of the paper have to say:

The strongest evidence that containment, on the path to elimination, works comes from the remarkable success of China in reversing a large pandemic.  Of particular relevance to New Zealand are the examples of smaller Asian jurisdictions, notably Hong Kong, Singapore, South Korea and Taiwan.’

In the UK the stable door was left wide open and the horse has well and truly bolted. We have had 20,000+ deaths so far and to get out of ‘lockdown’ we are going to have to have in place the measures which might have eliminated some of this pain if they had been applied earlier, detection identified by widespread testing, case isolation, contact tracing and quarantine for contacts. Questions need to be asked of someone.

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