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by Les May
THE new vaccine developed to provide protection against the SARS Cov2 virus which causes the disease which we know as Covid 19, has one huge advantage; it does not contain any attenuated or killed virus particles. Potentially this makes it an even safer candidate for extensive use.
The four letters mRNA stand for messenger RiboNucleicAcid. Viruses whether they infect, bacteria, fungi, plants or animals, are essentially strings of instructions, (messages) which tell infected cells what to produce and how it should assemble the components. An mRNA vaccine works by copying just a small part of these instructions. It’s the bit which instructs the cell how to produce just the molecules (antigens) found on the surface of the virus which the immune system of our body recognises. The immune system then produces antibodies which can lock onto the antigen on the surface of any virus particles if the individual becomes infected.
Because the synthesis of the mRNA is essentially a chemical process done in the laboratory there is no possibility of virus particles being introduced into the vaccine. But there’s some bad new as well.
The molecules of mRNA are not stable at higher temperatures and in this case ‘higher temperatures’ are still very much colder than your average deep freeze. After manufacture the vaccine must be kept at about minus 80 degrees Celsius at all times, otherwise it will degrade and become non-functional.
This is not a problem for laboratories and hospitals, but it is for local surgeries and pharmacies, both of which have been suggested as locations where the vaccine could be administered.
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